{"id":845,"date":"2023-07-20T20:46:16","date_gmt":"2023-07-20T20:46:16","guid":{"rendered":"https:\/\/chemuza.org\/tr\/dimetil-fumarat-c6h8o4\/"},"modified":"2023-07-20T20:46:16","modified_gmt":"2023-07-20T20:46:16","slug":"dimetil-fumarat-c6h8o4","status":"publish","type":"post","link":"https:\/\/chemuza.org\/tr\/dimetil-fumarat-c6h8o4\/","title":{"rendered":"Dimetil fumarat \u2013 c6h8o4, 624-49-7"},"content":{"rendered":"<p>Dimetil fumarat (DMF), multipl sklerozu tedavi etmek i\u00e7in t\u0131bbi olarak kullan\u0131lan bir bile\u015fiktir. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemini mod\u00fcle ederek inflamasyonu ve n\u00fcksetme oranlar\u0131n\u0131 azalt\u0131r.<\/p>\n<figure class=\"wp-block-table\">\n<table>\n<tbody>\n<tr>\n<td> IUPAC&#8217;\u0131n ad\u0131<\/td>\n<td> (E)-but-2-endioik asit dimetil ester<\/td>\n<\/tr>\n<tr>\n<td> Molek\u00fcler form\u00fcl<\/td>\n<td> C6H8O4<\/td>\n<\/tr>\n<tr>\n<td> CAS numaras\u0131<\/td>\n<td> 624-49-7<\/td>\n<\/tr>\n<tr>\n<td> E\u015f anlaml\u0131<\/td>\n<td> DMF, Bioban, Fumaderm, Tecfidera, Dimetil (E)-b\u00fctendioat<\/td>\n<\/tr>\n<tr>\n<td> InChI<\/td>\n<td> InChI=1S\/C6H8O4\/c1-9-5(7)3-4-6(8)10-2\/h3-4H,1-2H3\/b4-3+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h2 class=\"wp-block-heading\"> <strong>Dimetil fumarat\u0131n \u00f6zellikleri<\/strong><\/h2>\n<h3 class=\"wp-block-heading\"> Dimetil Fumarat Form\u00fcl\u00fc<\/h3>\n<p> Dimetil fumarat\u0131n kimyasal form\u00fcl\u00fc C6H8O4&#8217;t\u00fcr. 6 karbon (C), 8 hidrojen (H) atomu ve 4 oksijen (O) atomundan olu\u015fan bile\u015fikte bulunan atomlar\u0131n spesifik d\u00fczenini ve t\u00fcrlerini temsil eder. Form\u00fcl, dimetil fumarat\u0131n elementel bile\u015fiminin k\u0131sa bir temsilini sa\u011flar.<\/p>\n<h3 class=\"wp-block-heading\"> Dimetil Fumarat Molar K\u00fctlesi<\/h3>\n<p> DMF&#8217;nin molar k\u00fctlesi, onu olu\u015fturan t\u00fcm elementlerin atomik k\u00fctleleri toplanarak hesaplan\u0131r. C6H8O4 molek\u00fcler form\u00fcl\u00fcyle molar k\u00fctle, mol ba\u015f\u0131na yakla\u015f\u0131k 144,13 gramd\u0131r. Bu de\u011fer, DMF&#8217;yi i\u00e7eren \u00e7e\u015fitli kimyasal hesaplamalar ve d\u00f6n\u00fc\u015f\u00fcmler i\u00e7in \u00e7ok \u00f6nemlidir.<\/p>\n<h3 class=\"wp-block-heading\"> Dimetil fumarat\u0131n kaynama noktas\u0131<\/h3>\n<p> DMF&#8217;nin kaynama noktas\u0131 yakla\u015f\u0131k 191 santigrat derece (376 Fahrenheit derece)&#8217;dir. Kaynama noktas\u0131, s\u0131v\u0131 bile\u015fi\u011fin gaz haline d\u00f6n\u00fc\u015ft\u00fc\u011f\u00fc s\u0131cakl\u0131k anlam\u0131na gelir ve DMF durumunda bu, s\u00f6z konusu s\u0131cakl\u0131kta ger\u00e7ekle\u015fir.<\/p>\n<h3 class=\"wp-block-heading\"> Dimetil fumarat Erime noktas\u0131<\/h3>\n<p> DMF&#8217;nin erime noktas\u0131 yakla\u015f\u0131k 102 santigrat derecedir (216 Fahrenheit derece). Bu s\u0131cakl\u0131k, bile\u015fi\u011fin kat\u0131 formunun s\u0131v\u0131 duruma ge\u00e7ti\u011fi noktay\u0131 temsil eder. DMF, belirtilen erime noktas\u0131nda bu faz de\u011fi\u015fimine u\u011frar.<\/p>\n<h3 class=\"wp-block-heading\"> Dimetil fumarat\u0131n yo\u011funlu\u011fu g\/mL<\/h3>\n<p> DMF&#8217;nin yo\u011funlu\u011fu mililitre ba\u015f\u0131na yakla\u015f\u0131k 1,30 gramd\u0131r (g\/mL). Yo\u011funluk, bir maddenin belirli bir hacminde bulunan k\u00fctlenin bir \u00f6l\u00e7\u00fcs\u00fcd\u00fcr. DMF durumunda, bile\u015fi\u011fin her mililitresindeki k\u00fctle konsantrasyonunu g\u00f6sterir.<\/p>\n<h3 class=\"wp-block-heading\"> Dimetil Fumarat Molek\u00fcl A\u011f\u0131rl\u0131\u011f\u0131<\/h3>\n<p> Molar k\u00fctle olarak da adland\u0131r\u0131lan DMF&#8217;nin molek\u00fcler a\u011f\u0131rl\u0131\u011f\u0131, mol ba\u015f\u0131na yakla\u015f\u0131k 144,13 gramd\u0131r. Bir DMF molek\u00fcl\u00fcnde bulunan t\u00fcm atomlar\u0131n atom a\u011f\u0131rl\u0131klar\u0131n\u0131n toplam\u0131d\u0131r. Molek\u00fcl a\u011f\u0131rl\u0131\u011f\u0131 \u00e7e\u015fitli kimyasal hesaplamalar ve analizler i\u00e7in \u00e7ok \u00f6nemlidir. <\/p>\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/chemuza.org\/wp-content\/uploads\/2023\/08\/DMF.jpg\" alt=\"Dimetil fumarat\" width=\"178\" height=\"88\" srcset=\"\" sizes=\"\"><\/figure>\n<\/div>\n<h3 class=\"wp-block-heading\"> Dimetil fumarat\u0131n yap\u0131s\u0131<\/h3>\n<p> DMF&#8217;nin yap\u0131s\u0131, merkezi bir fumarat k\u0131sm\u0131na ba\u011fl\u0131 iki metil grubundan (CH3) olu\u015fur. Fumarat k\u0131sm\u0131, \u00e7ift ba\u011f ile birle\u015ftirilen iki karboksilat grubundan olu\u015fur. Bu d\u00fczenleme DMF&#8217;ye karakteristik \u015feklini ve kimyasal \u00f6zelliklerini verir.<\/p>\n<h3 class=\"wp-block-heading\"> Dimetil fumarat\u0131n \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fc<\/h3>\n<p> DMF suda az \u00e7\u00f6z\u00fcn\u00fcr ancak etanol veya metanol gibi organik \u00e7\u00f6z\u00fcc\u00fclerde kolayca \u00e7\u00f6z\u00fcn\u00fcr. Bu s\u0131n\u0131rl\u0131 su \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fc, DMF ve bunun \u00e7e\u015fitli end\u00fcstrilerdeki uygulamalar\u0131 ile \u00e7al\u0131\u015f\u0131rken dikkate al\u0131nmas\u0131 gereken bir fakt\u00f6rd\u00fcr.<\/p>\n<figure class=\"wp-block-table\">\n<table>\n<tbody>\n<tr>\n<td> D\u0131\u015f g\u00f6r\u00fcn\u00fc\u015f<\/td>\n<td> Renksiz kristaller veya beyaz toz<\/td>\n<\/tr>\n<tr>\n<td> Spesifik yer \u00e7ekimi<\/td>\n<td> 1 saat 30<\/td>\n<\/tr>\n<tr>\n<td> Renk<\/td>\n<td> Renksiz<\/td>\n<\/tr>\n<tr>\n<td> Koku<\/td>\n<td> Kokusuz<\/td>\n<\/tr>\n<tr>\n<td> Molar k\u00fctle<\/td>\n<td> 144,13 gr\/mol<\/td>\n<\/tr>\n<tr>\n<td> Yo\u011funluk<\/td>\n<td> 1.30g\/ml<\/td>\n<\/tr>\n<tr>\n<td> F\u00fczyon noktas\u0131<\/td>\n<td> 102\u00b0C (216\u00b0F)<\/td>\n<\/tr>\n<tr>\n<td> Kaynama noktas\u0131<\/td>\n<td> 191\u00b0C (376\u00b0F)<\/td>\n<\/tr>\n<tr>\n<td> Fla\u015f noktas\u0131<\/td>\n<td> M\u00fcsait de\u011fil<\/td>\n<\/tr>\n<tr>\n<td> sudaki \u00e7\u00f6z\u00fcn\u00fcrl\u00fck<\/td>\n<td> Az \u00e7\u00f6z\u00fcn\u00fcr<\/td>\n<\/tr>\n<tr>\n<td> \u00e7\u00f6z\u00fcn\u00fcrl\u00fck<\/td>\n<td> Organik \u00e7\u00f6z\u00fcc\u00fclerde \u00e7\u00f6z\u00fcn\u00fcr (\u00f6rne\u011fin etanol, metanol)<\/td>\n<\/tr>\n<tr>\n<td> Buhar bas\u0131nc\u0131<\/td>\n<td> M\u00fcsait de\u011fil<\/td>\n<\/tr>\n<tr>\n<td> Buhar yo\u011funlu\u011fu<\/td>\n<td> M\u00fcsait de\u011fil<\/td>\n<\/tr>\n<tr>\n<td> pKa<\/td>\n<td> M\u00fcsait de\u011fil<\/td>\n<\/tr>\n<tr>\n<td> pH<\/td>\n<td> M\u00fcsait de\u011fil<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h2 class=\"wp-block-heading\"> <strong>Dimetil fumarat\u0131n g\u00fcvenli\u011fi ve tehlikeleri<\/strong><\/h2>\n<p> G\u00fcvenli\u011fi sa\u011flamak i\u00e7in DMF dikkatle kullan\u0131lmal\u0131d\u0131r. Cilt, g\u00f6z veya solunum sistemi ile temas\u0131 halinde tahri\u015fe neden olabilir. Kullan\u0131rken yeterli havaland\u0131rma ve eldiven ve g\u00f6zl\u00fck gibi koruyucu ekipmanlar\u0131n kullan\u0131lmas\u0131 tavsiye edilir. Sa\u011fl\u0131k risklerine neden olabilece\u011finden DMF&#8217;nin yutulmas\u0131 veya solunmas\u0131ndan ka\u00e7\u0131n\u0131lmal\u0131d\u0131r. Kazara maruz kalma durumunda derhal t\u0131bbi m\u00fcdahale gereklidir. Uygun depolama kurallar\u0131na uymak ve bile\u015fi\u011fi a\u00e7\u0131k alevlerden veya \u0131s\u0131 kaynaklar\u0131ndan uzak tutmak \u00f6nemlidir. G\u00fcvenlik protokollerine uyum, DMF ile ili\u015fkili riskleri en aza indirir.<\/p>\n<figure class=\"wp-block-table\">\n<table>\n<tbody>\n<tr>\n<td> Tehlike sembolleri<\/td>\n<td> Hi\u00e7biri<\/td>\n<\/tr>\n<tr>\n<td> G\u00fcvenlik A\u00e7\u0131klamas\u0131<\/td>\n<td> Cilt, g\u00f6z ve solunum sistemi ile temas\u0131ndan ka\u00e7\u0131n\u0131n. Yeterli havaland\u0131rmay\u0131 sa\u011flay\u0131n. Koruyucu ekipman kullan\u0131n (eldiven, g\u00f6zl\u00fck). Yutmaktan ve solumaktan ka\u00e7\u0131n\u0131n. Maruz kal\u0131nmas\u0131 halinde derhal t\u0131bbi yard\u0131ma ba\u015fvurun. A\u00e7\u0131k alevlerden veya \u0131s\u0131 kaynaklar\u0131ndan uzak tutun.<\/td>\n<\/tr>\n<tr>\n<td> BM kimlik numaralar\u0131<\/td>\n<td> Uygulanamaz<\/td>\n<\/tr>\n<tr>\n<td> HS kodu<\/td>\n<td> 2917.19.90<\/td>\n<\/tr>\n<tr>\n<td> Tehlike s\u0131n\u0131f\u0131<\/td>\n<td> s\u0131n\u0131fland\u0131r\u0131lmam\u0131\u015f<\/td>\n<\/tr>\n<tr>\n<td> Paketleme grubu<\/td>\n<td> Uygulanamaz<\/td>\n<\/tr>\n<tr>\n<td> Toksisite<\/td>\n<td> Cilt ve g\u00f6z tahri\u015fine neden olabilir. Yutmaktan ve solumaktan ka\u00e7\u0131n\u0131n.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h2 class=\"wp-block-heading\"> <strong>Dimetil fumarat\u0131n sentezi i\u00e7in y\u00f6ntemler<\/strong><\/h2>\n<p> DMF&#8217;yi sentezlemek i\u00e7in farkl\u0131 y\u00f6ntemler vard\u0131r.<\/p>\n<p> Yayg\u0131n bir yakla\u015f\u0131m, fumarik asidin <a href=\"https:\/\/chemuza.org\/tr\/ch3oh-metanol\/\">metanol<\/a> kullan\u0131larak esterifikasyonunu i\u00e7erir. Bu reaksiyonda s\u00fclf\u00fcrik asit veya p-tol\u00fcens\u00fclfonik asit, fumarik asidi <a href=\"https:\/\/chemuza.org\/tr\/ch3oh-metanol\/\">metanol<\/a> ile birle\u015ftirmek i\u00e7in asit kataliz\u00f6r\u00fc g\u00f6revi g\u00f6r\u00fcr. Reaksiyon, esterle\u015fme s\u00fcrecini kolayla\u015ft\u0131rmak i\u00e7in geri ak\u0131\u015f ko\u015fullar\u0131 alt\u0131nda, genellikle y\u00fcksek bir s\u0131cakl\u0131kta ger\u00e7ekle\u015fir. Asit kataliz\u00f6r\u00fc, yan \u00fcr\u00fcn olarak neden oldu\u011fu suyun uzakla\u015ft\u0131r\u0131lmas\u0131n\u0131 kolayla\u015ft\u0131rarak reaksiyonu aktif olarak destekler.<\/p>\n<p> Ba\u015fka bir y\u00f6ntem, maleik anhidr\u00fcr\u00fcn <a href=\"https:\/\/chemuza.org\/tr\/ch3oh-metanol\/\">metanol<\/a> ile reaksiyonunu i\u00e7erir. Maleik anhidrit ve metanol, <a href=\"https:\/\/chemuza.org\/tr\/sulfurik-asit-vitriol-yagi-h2so4\/\">s\u00fclf\u00fcrik asit<\/a> veya fosforik asit gibi asidik bir kataliz\u00f6r varl\u0131\u011f\u0131nda reaksiyona girerek DMF&#8217;yi \u00fcretir. Reaksiyon, siklik anhidrit halkas\u0131n\u0131n a\u00e7\u0131lmas\u0131 ve ard\u0131ndan esterifikasyon yoluyla ger\u00e7ekle\u015fir.<\/p>\n<p> DMF&#8217;yi haz\u0131rlamak i\u00e7in dimetil maleat kullan\u0131larak bir transesterifikasyon reaksiyonu ger\u00e7ekle\u015ftirilebilir. Bu i\u015flemde dimetil maleat, sodyum metoksit veya <a href=\"https:\/\/chemuza.org\/tr\/kostik-potas-potasyum-hidroksit-koh\/\">potasyum hidroksit<\/a> gibi bir kataliz\u00f6r mevcutken <a href=\"https:\/\/chemuza.org\/tr\/ch3oh-metanol\/\">metanol<\/a> ile reaksiyona girer. Transesterifikasyon reaksiyonu DMF olu\u015fumuna yol a\u00e7ar.<\/p>\n<p> Bu sentez y\u00f6ntemleri, laboratuvar veya end\u00fcstriyel ortamda DMF elde etmek i\u00e7in yollar sa\u011flar. Her y\u00f6ntemin kendine g\u00f6re avantajlar\u0131 oldu\u011fundan verimlilik, verim ve hammadde bulunabilirli\u011fi gibi fakt\u00f6rler her y\u00f6ntemin se\u00e7imini belirler. Sentezlenen DMF&#8217;nin istenen safl\u0131\u011f\u0131n\u0131 ve kalitesini sa\u011flamak i\u00e7in reaksiyon ko\u015fullar\u0131n\u0131n ve safla\u015ft\u0131rma ad\u0131mlar\u0131n\u0131n uygun \u015fekilde kontrol edilmesi \u00f6nemlidir.<\/p>\n<h2 class=\"wp-block-heading\"> <strong>Dimetil Fumarat\u0131n Kullan\u0131m Alanlar\u0131<\/strong><\/h2>\n<p> DMF, \u00e7e\u015fitli \u00f6zelliklerinden dolay\u0131 \u00e7e\u015fitli alanlarda uygulama alan\u0131 bulmaktad\u0131r. \u0130\u015fte DMF&#8217;nin baz\u0131 kullan\u0131mlar\u0131:<\/p>\n<ul>\n<li> Multipl skleroz tedavisi: FDA, DMF&#8217;yi multipl sklerozun tekrarlayan formlar\u0131n\u0131 tedavi etmek i\u00e7in bir ila\u00e7 olarak onaylad\u0131. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemini mod\u00fcle ederek n\u00fcksetme oranlar\u0131n\u0131 ve iltihab\u0131 azaltmaya yard\u0131mc\u0131 olur.<\/li>\n<li> \u0130la\u00e7 end\u00fcstrisi: Farmas\u00f6tik bile\u015fikler, sentezlerinde DMF&#8217;yi bir ara madde olarak kullan\u0131r. \u00c7e\u015fitli ila\u00e7lar\u0131n \u00fcretiminin temelini olu\u015fturur.<\/li>\n<li> Antimikrobiyal ajan: DMF antimikrobiyal \u00f6zellikler g\u00f6sterir. Boya, kaplama ve yap\u0131\u015ft\u0131r\u0131c\u0131 gibi \u00fcr\u00fcnlerde koruyucu olarak uygulama alan\u0131 bulur. Mikroorganizmalar\u0131n b\u00fcy\u00fcmesini engellemeye ve bozulmay\u0131 \u00f6nlemeye yard\u0131mc\u0131 olur.<\/li>\n<li> Tekstil End\u00fcstrisi: Tekstil end\u00fcstrisi, depolama ve nakliye s\u0131ras\u0131nda kuma\u015flarda k\u00fcf ve mantar olu\u015fumunu engellemek i\u00e7in g\u00fc\u00e7l\u00fc bir biyosit olarak DMF&#8217;yi kullan\u0131r.<\/li>\n<li> Mobilya ve Deri E\u015fyalar: Mobilya, deri e\u015fya ve ayakkab\u0131 \u00fcretiminde \u00fcreticiler DMF&#8217;yi k\u00fcf \u00f6nleyici olarak kullan\u0131yor. Bu e\u015fyalar\u0131n depolama ve nakliye s\u0131ras\u0131nda mikrobiyal hasardan korunmas\u0131na yard\u0131mc\u0131 olur.<\/li>\n<li> Polimer stabilizat\u00f6r\u00fc: DMF, polipropilen ve polietilen gibi polimerlerde stabilizat\u00f6r ve antioksidan g\u00f6revi g\u00f6r\u00fcr. Bu, termal stabilitelerini art\u0131rmaya ve raf \u00f6mr\u00fcn\u00fc uzatmaya yard\u0131mc\u0131 olur.<\/li>\n<li> Kimyasal Reaktif: Esterifikasyonlar ve transesterifikasyonlar dahil olmak \u00fczere \u00e7e\u015fitli kimyasal reaksiyonlarda reaktif olarak DMF kullan\u0131l\u0131r. Esterlerin ve di\u011fer organik bile\u015fiklerin sentezini kolayla\u015ft\u0131r\u0131r.<\/li>\n<\/ul>\n<p> Bunlar DMF&#8217;nin end\u00fcstriler aras\u0131ndaki \u00e7e\u015fitli uygulamalar\u0131na sadece birka\u00e7 \u00f6rnektir. E\u015fsiz \u00f6zellikleri onu t\u0131pta, imalatta, korumada ve kimyada de\u011ferli bir bile\u015fik haline getirir.<\/p>\n<h2 class=\"wp-block-heading\"> <strong>Sorular:<\/strong><\/h2>\n<h3 class=\"wp-block-heading\"> S: Dimetil fumarat\u0131 mobilyalardan nas\u0131l \u00e7\u0131karabilirim?<\/h3>\n<p> C: DMF, etkilenen b\u00f6lgeleri yumu\u015fak bir sabun \u00e7\u00f6zeltisiyle silerek veya lekeleri ve kal\u0131nt\u0131lar\u0131 \u00e7\u0131karmak i\u00e7in \u00f6zel olarak tasarlanm\u0131\u015f bir temizlik maddesi kullan\u0131larak mobilyalardan \u00e7\u0131kar\u0131labilir.<\/p>\n<h3 class=\"wp-block-heading\"> S: Hangisi daha polar, dietil maleat m\u0131 yoksa dimetil fumarat m\u0131?<\/h3>\n<p> C: DMF, yap\u0131s\u0131nda elektron \u00e7ekici karbonil gruplar\u0131n\u0131n bulunmas\u0131 nedeniyle dietil maleattan daha polard\u0131r.<\/p>\n<h3 class=\"wp-block-heading\"> S: Dimetil fumarat ne i\u00e7in kullan\u0131l\u0131r?<\/h3>\n<p> C: DMF, multipl skleroz tedavisinde kullan\u0131l\u0131r ve ayn\u0131 zamanda ila\u00e7 end\u00fcstrisinde, koruyucu olarak, ayr\u0131ca tekstil ve polimer end\u00fcstrilerinde de uygulama alan\u0131 bulur.<\/p>\n<h3 class=\"wp-block-heading\"> S: Dimetil maleat ve dimetil fumaratta bulunan iki fonksiyonel grup nelerdir?<\/h3>\n<p> C: Dimetil maleat ve DMF&#8217;nin her ikisi de ester ve alken fonksiyonel gruplar\u0131 i\u00e7erir.<\/p>\n<h3 class=\"wp-block-heading\"> S: Dimetil fumarat\u0131n kokusuna alerjiniz olabilir mi?<\/h3>\n<p> C: Evet, baz\u0131 insanlar DMF kokusuna kar\u015f\u0131 alerjik reaksiyonlar geli\u015ftirebilir ve bu da cilt tahri\u015fi, nefes alma sorunlar\u0131 veya alerjik dermatit gibi semptomlara neden olabilir.<\/p>\n<h3 class=\"wp-block-heading\"> S: Dimetil maleat ve dimetil fumarat geri d\u00f6n\u00fc\u015f\u00fcml\u00fc m\u00fcd\u00fcr?<\/h3>\n<p> C: Hay\u0131r, dimetil maleat ve DMF geri d\u00f6n\u00fc\u015f\u00fcml\u00fc de\u011fildir. Bunlar ayn\u0131 bile\u015fi\u011fin farkl\u0131 izomerleridir ve kolayca birbirine d\u00f6n\u00fc\u015fmezler.<\/p>\n<h3 class=\"wp-block-heading\"> S: Reaksiyon \u00fcr\u00fcn\u00fc dimetil fumarat&#8217;\u0131 safla\u015ft\u0131rmak i\u00e7in hangi laboratuvar tekni\u011fini kullanacaks\u0131n\u0131z?<\/h3>\n<p> C: Dam\u0131tma, DMF reaksiyon \u00fcr\u00fcn\u00fcn\u00fc kaynama noktalar\u0131ndaki farkl\u0131l\u0131klara dayal\u0131 olarak yabanc\u0131 maddelerden ay\u0131rarak safla\u015ft\u0131rmak i\u00e7in yayg\u0131n olarak kullan\u0131l\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dimetil fumarat (DMF), multipl sklerozu tedavi etmek i\u00e7in t\u0131bbi olarak kullan\u0131lan bir bile\u015fiktir. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemini mod\u00fcle ederek inflamasyonu ve n\u00fcksetme oranlar\u0131n\u0131 azalt\u0131r. IUPAC&#8217;\u0131n ad\u0131 (E)-but-2-endioik asit dimetil ester Molek\u00fcler form\u00fcl C6H8O4 CAS numaras\u0131 624-49-7 E\u015f anlaml\u0131 DMF, Bioban, Fumaderm, Tecfidera, Dimetil (E)-b\u00fctendioat InChI InChI=1S\/C6H8O4\/c1-9-5(7)3-4-6(8)10-2\/h3-4H,1-2H3\/b4-3+ Dimetil fumarat\u0131n \u00f6zellikleri Dimetil Fumarat Form\u00fcl\u00fc Dimetil fumarat\u0131n kimyasal form\u00fcl\u00fc C6H8O4&#8217;t\u00fcr. &#8230; <a title=\"Dimetil fumarat \u2013 c6h8o4, 624-49-7\" class=\"read-more\" href=\"https:\/\/chemuza.org\/tr\/dimetil-fumarat-c6h8o4\/\" aria-label=\"More on Dimetil fumarat \u2013 c6h8o4, 624-49-7\">Devam\u0131n\u0131 oku<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dimetil fumarat - C6H8O4, 624-49-7<\/title>\n<meta name=\"description\" content=\"Dimetil fumarat (DMF), multipl sklerozu tedavi etmek i\u00e7in t\u0131bbi olarak kullan\u0131lan bir bile\u015fiktir. 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