{"id":474,"date":"2023-07-23T03:37:45","date_gmt":"2023-07-23T03:37:45","guid":{"rendered":"https:\/\/chemuza.org\/ja\/4-%e3%82%a2%e3%83%9f%e3%83%8e%e5%ae%89%e6%81%af%e9%a6%99%e9%85%b8%e3%82%a8%e3%83%81%e3%83%ab-c9h11no2-94-09-7\/"},"modified":"2023-07-23T03:37:45","modified_gmt":"2023-07-23T03:37:45","slug":"4-%e3%82%a2%e3%83%9f%e3%83%8e%e5%ae%89%e6%81%af%e9%a6%99%e9%85%b8%e3%82%a8%e3%83%81%e3%83%ab-c9h11no2-94-09-7","status":"publish","type":"post","link":"https:\/\/chemuza.org\/ja\/4-%e3%82%a2%e3%83%9f%e3%83%8e%e5%ae%89%e6%81%af%e9%a6%99%e9%85%b8%e3%82%a8%e3%83%81%e3%83%ab-c9h11no2-94-09-7\/","title":{"rendered":"4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb \u2013 c9h11no2\u300194-09-7"},"content":{"rendered":"<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308b 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306f\u3001\u6b6f\u79d1\u51e6\u7f6e\u3084\u5c40\u6240\u93ae\u75db\u88fd\u54c1\u306b\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u5c40\u6240\u9ebb\u9154\u85ac\u3067\u3059\u3002\u795e\u7d4c\u4fe1\u53f7\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002<\/p>\n<figure class=\"wp-block-table\">\n<table>\n<tbody>\n<tr>\n<td> IUPAC\u540d<\/td>\n<td>4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C9H11NO2<\/td>\n<\/tr>\n<tr>\n<td> CAS\u756a\u53f7<\/td>\n<td>94-09-7<\/td>\n<\/tr>\n<tr>\n<td>\u540c\u7fa9\u8a9e<\/td>\n<td>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3001p-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u30a8\u30b9\u30c6\u30eb\u3001\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u3001p-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u3001\u5b89\u606f\u9999\u91784-(\u30a8\u30c8\u30ad\u30b7\u30ab\u30eb\u30dc\u30cb\u30eb)\u30a2\u30cb\u30ea\u30cb\u30a6\u30e0<\/td>\n<\/tr>\n<tr>\n<td>\u30a4\u30f3\u30c1\u30c1<\/td>\n<td>InChI=1S\/C9H11NO2\/c1-2-12-9(11)7-3-5-8(10)6-4-7\/h3-6H,2,10H2,1H3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h6 class=\"wp-block-heading\"> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u30e2\u30eb\u8cea\u91cf:<\/h6>\n<p> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u30e2\u30eb\u8cea\u91cf\u306f 165.19 g\/mol \u3067\u3059\u3002\u30e2\u30eb\u8cea\u91cf\u306f\u7269\u8cea 1 \u30e2\u30eb\u306e\u8cea\u91cf\u3067\u3042\u308a\u3001\u5206\u5b50\u5185\u306e\u3059\u3079\u3066\u306e\u539f\u5b50\u306e\u539f\u5b50\u8cea\u91cf\u3092\u52a0\u7b97\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8a08\u7b97\u3055\u308c\u307e\u3059\u3002\u30e2\u30eb\u8cea\u91cf\u306f\u5316\u5b66\u53cd\u5fdc\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30d1\u30e9\u30e1\u30fc\u30bf\u3067\u3042\u308a\u3001\u30b5\u30f3\u30d7\u30eb\u4e2d\u306b\u5b58\u5728\u3059\u308b\u7269\u8cea\u306e\u91cf\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n<h6 class=\"wp-block-heading\"> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u6cb8\u70b9:<\/h6>\n<p> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u6cb8\u70b9\u306f310.7\u2103\u3067\u3059\u3002\u6cb8\u70b9\u306f\u3001\u6db2\u4f53\u306e\u84b8\u6c17\u5727\u304c\u5916\u90e8\u5727\u529b\u3068\u7b49\u3057\u304f\u306a\u308b\u6e29\u5ea6\u3067\u3059\u3002\u6cb8\u70b9\u3067\u306f\u3001\u7269\u8cea\u306f\u6db2\u4f53\u304b\u3089\u6c17\u4f53\u306b\u76f8\u8ee2\u79fb\u3057\u307e\u3059\u3002 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306f\u6cb8\u70b9\u304c\u9ad8\u3044\u305f\u3081\u3001\u9ad8\u6e29\u3092\u4f34\u3046\u6b6f\u79d1\u304a\u3088\u3073\u533b\u7642\u51e6\u7f6e\u3067\u306e\u4f7f\u7528\u306b\u9069\u3057\u305f\u5316\u5408\u7269\u3067\u3059\u3002<\/p>\n<h6 class=\"wp-block-heading\"> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u878d\u70b9:<\/h6>\n<p> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u878d\u70b9\u306f89\uff5e92\u2103\u3067\u3059\u3002\u878d\u70b9\u3068\u306f\u3001\u56fa\u4f53\u7269\u8cea\u304c\u6db2\u4f53\u72b6\u614b\u306b\u5909\u5316\u3059\u308b\u6e29\u5ea6\u3067\u3059\u3002\u5316\u5408\u7269\u306e\u878d\u70b9\u306f\u3001\u305d\u306e\u5316\u5b66\u69cb\u9020\u3001\u7d14\u5ea6\u3001\u5727\u529b\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306f\u878d\u70b9\u304c\u4f4e\u3044\u305f\u3081\u3001\u53d6\u308a\u6271\u3044\u304c\u5bb9\u6613\u3067\u3001\u5c40\u6240\u9ebb\u9154\u85ac\u3084\u93ae\u75db\u85ac\u306e\u8abf\u88fd\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002<\/p>\n<h6 class=\"wp-block-heading\"> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u5bc6\u5ea6 g\/ml:<\/h6>\n<p> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u5bc6\u5ea6\u306f 1.17 g\/mL \u3067\u3059\u3002\u5bc6\u5ea6\u306f\u3001\u7269\u8cea\u306e\u5358\u4f4d\u4f53\u7a4d\u3042\u305f\u308a\u306e\u8cea\u91cf\u3067\u3059\u3002\u5316\u5408\u7269\u306e\u5bc6\u5ea6\u306f\u3001\u305d\u306e\u5206\u5b50\u91cf\u3001\u6e29\u5ea6\u3001\u5727\u529b\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306f\u9ad8\u5bc6\u5ea6\u3067\u3042\u308b\u305f\u3081\u3001\u91cd\u3044\u5316\u5408\u7269\u3068\u306a\u308a\u3001\u7c21\u5358\u306b\u6e2c\u5b9a\u3067\u304d\u3001\u5316\u5b66\u53cd\u5fdc\u306b\u6b63\u78ba\u306a\u91cf\u3067\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u5206\u5b50\u91cf:<\/p>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u5206\u5b50\u91cf\u306f 165.19 g\/mol \u3067\u3059\u3002\u5206\u5b50\u91cf\u306f\u3001\u5206\u5b50\u5185\u306e\u3059\u3079\u3066\u306e\u539f\u5b50\u306e\u539f\u5b50\u91cf\u306e\u5408\u8a08\u3067\u3059\u3002\u5316\u5408\u7269\u306e\u5206\u5b50\u91cf\u306f\u3001\u305d\u306e\u7269\u7406\u7684\u304a\u3088\u3073\u5316\u5b66\u7684\u7279\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u969b\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u69cb\u9020: <\/p>\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/chemuza.org\/wp-content\/uploads\/2023\/08\/benzocaine.png\" alt=\"4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\" width=\"227\" height=\"106\" srcset=\"\" sizes=\"\"><\/figure>\n<\/div>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u69cb\u9020\u306f\u3001\u5316\u5b66\u5f0f C9H11NO2 \u306e\u767d\u8272\u306e\u7d50\u6676\u6027\u7c89\u672b\u3067\u3059\u3002\u30d9\u30f3\u30bc\u30f3\u74b0\u306b\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u3068\u30a2\u30df\u30ce\u57fa\u304c\u7d50\u5408\u3057\u3066\u3044\u307e\u3059\u3002\u30a8\u30c1\u30eb\u57fa\u304c\u30a2\u30df\u30ce\u57fa\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u5b89\u606f\u9999\u9178\u306e\u8a98\u5c0e\u4f53\u3068\u306a\u308a\u307e\u3059\u3002\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u69cb\u9020\u306f\u3001\u305d\u306e\u7269\u7406\u7684\u304a\u3088\u3073\u5316\u5b66\u7684\u7279\u6027\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u5f0f:<\/p>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u5316\u5b66\u5f0f\u306f C9H11NO2 \u3067\u3059\u3002\u3053\u308c\u306f\u5b89\u606f\u9999\u9178\u306e\u8a98\u5c0e\u4f53\u3067\u3042\u308a\u3001\u30a2\u30df\u30ce\u57fa\u306b\u30a8\u30c1\u30eb\u57fa\u304c\u7d50\u5408\u3057\u3066\u3044\u307e\u3059\u3002\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306e\u5f0f\u306f\u5316\u5408\u7269\u306e\u7d44\u6210\u3092\u8868\u3059\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u3001\u305d\u306e\u7269\u7406\u7684\u304a\u3088\u3073\u5316\u5b66\u7684\u7279\u6027\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n<figure class=\"wp-block-table\">\n<table>\n<tbody>\n<tr>\n<td>\u5916\u89b3<\/td>\n<td>\u767d\u8272\u306e\u7d50\u6676\u6027\u7c89\u672b<\/td>\n<\/tr>\n<tr>\n<td>\u6bd4\u91cd<\/td>\n<td>1.17g\/ml<\/td>\n<\/tr>\n<tr>\n<td>\u8272<\/td>\n<td>\u7121\u8272\uff5e\u767d\u8272<\/td>\n<\/tr>\n<tr>\n<td>\u5302\u3044<\/td>\n<td>\u7121\u81ed<\/td>\n<\/tr>\n<tr>\n<td>\u30e2\u30eb\u8cea\u91cf<\/td>\n<td>165.19 g\/\u30e2\u30eb<\/td>\n<\/tr>\n<tr>\n<td>\u5bc6\u5ea6<\/td>\n<td>1.17g\/ml<\/td>\n<\/tr>\n<tr>\n<td>\u878d\u5408\u70b9<\/td>\n<td>89\uff5e92\u2103<\/td>\n<\/tr>\n<tr>\n<td>\u6cb8\u70b9<\/td>\n<td>310.7\u2103<\/td>\n<\/tr>\n<tr>\n<td>\u30d5\u30e9\u30c3\u30b7\u30e5\u30c9\u30c3\u30c8<\/td>\n<td>164.2\u2103<\/td>\n<\/tr>\n<tr>\n<td>\u6c34\u3078\u306e\u6eb6\u89e3\u5ea6<\/td>\n<td>\u308f\u305a\u304b\u306b\u6eb6\u3051\u308b<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u30a8\u30bf\u30ce\u30fc\u30eb\u3001\u30af\u30ed\u30ed\u30db\u30eb\u30e0\u3001\u30a8\u30fc\u30c6\u30eb\u306b\u53ef\u6eb6<\/td>\n<\/tr>\n<tr>\n<td>\u84b8\u6c17\u5727<\/td>\n<td>1.07E-07 mmHg\uff0825\u2103\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u84b8\u6c17\u5bc6\u5ea6<\/td>\n<td>5.7 (\u5bfe\u7a7a)<\/td>\n<\/tr>\n<tr>\n<td> pKa<\/td>\n<td> 2.5<\/td>\n<\/tr>\n<tr>\n<td> pH<\/td>\n<td> 6.5 \u2013 7.5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h5 class=\"wp-block-heading\"> <strong>4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u5b89\u5168\u6027\u3068\u5371\u967a\u6027<\/strong><\/h5>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306f\u63a5\u89e6\u3059\u308b\u3068\u76ae\u819a\u3084\u76ee\u306b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5316\u5408\u7269\u3092\u6442\u53d6\u307e\u305f\u306f\u5438\u5165\u3059\u308b\u3068\u3001\u6d88\u5316\u5668\u7cfb\u307e\u305f\u306f\u547c\u5438\u5668\u7cfb\u306b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306b\u9577\u671f\u9593\u307e\u305f\u306f\u7e70\u308a\u8fd4\u3057\u66dd\u9732\u3055\u308c\u308b\u3068\u3001\u809d\u81d3\u307e\u305f\u306f\u814e\u81d3\u306b\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5316\u5408\u7269\u306f\u767a\u304c\u3093\u6027\u3084\u5909\u7570\u539f\u6027\u304c\u3042\u308b\u3068\u306f\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u53d6\u308a\u6271\u3044\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3092\u53d6\u308a\u6271\u3046\u3068\u304d\u306f\u3001\u624b\u888b\u3084\u5b89\u5168\u30e1\u30ac\u30cd\u306a\u3069\u306e\u9069\u5207\u306a\u500b\u4eba\u7528\u4fdd\u8b77\u5177\u3092\u7740\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6442\u53d6\u307e\u305f\u306f\u8aa4\u3063\u3066\u66b4\u9732\u3057\u305f\u5834\u5408\u306f\u3001\u76f4\u3061\u306b\u533b\u5e2b\u306e\u8a3a\u5bdf\u3092\u53d7\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306f\u3001\u6dbc\u3057\u304f\u4e7e\u71e5\u3057\u305f\u5834\u6240\u306b\u3001\u767a\u706b\u6e90\u3084\u71b1\u6e90\u304b\u3089\u9060\u3056\u3051\u3066\u4fdd\u7ba1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<figure class=\"wp-block-table\">\n<table>\n<tbody>\n<tr>\n<td>\u30cf\u30b6\u30fc\u30c9\u30b7\u30f3\u30dc\u30eb<\/td>\n<td>XI<\/td>\n<\/tr>\n<tr>\n<td>\u30bb\u30ad\u30e5\u30ea\u30c6\u30a3\u306e\u8aac\u660e<\/td>\n<td>S22-S24\/25-S36-S37<\/td>\n<\/tr>\n<tr>\n<td>\u56fd\u9023\u8b58\u5225\u756a\u53f7<\/td>\n<td>\u898f\u5236\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/td>\n<\/tr>\n<tr>\n<td>HS\u30b3\u30fc\u30c9<\/td>\n<td>29224990<\/td>\n<\/tr>\n<tr>\n<td>\u5371\u967a\u7b49\u7d1a<\/td>\n<td>\u523a\u6fc0\u7269<\/td>\n<\/tr>\n<tr>\n<td>\u68b1\u5305\u30b0\u30eb\u30fc\u30d7<\/td>\n<td>\u898f\u5236\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/td>\n<\/tr>\n<tr>\n<td>\u6bd2\u6027<\/td>\n<td>LD50 (\u30e9\u30c3\u30c8\u3001\u7d4c\u53e3) = 940 mg\/kg; LD50 (\u30e9\u30c3\u30c8\u3001\u76ae\u819a) &gt; 2 g\/kg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h5 class=\"wp-block-heading\"> <strong>4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u5408\u6210\u65b9\u6cd5<\/strong><\/h5>\n<p>\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308b\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u65b9\u6cd5\u3067\u5408\u6210\u3067\u304d\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u65b9\u6cd5\u306b\u306f\u3001\u786b\u9178\u3084\u5869\u9178\u306a\u3069\u306e\u5f37\u9178\u89e6\u5a92\u306e\u5b58\u5728\u4e0b\u3067\u306e p-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u3068\u30a8\u30bf\u30ce\u30fc\u30eb\u306e\u53cd\u5fdc\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u6b21\u3044\u3067\u3001\u5f97\u3089\u308c\u305f\uff50\uff0d\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u306e\u30a8\u30c1\u30eb\u30a8\u30b9\u30c6\u30eb\u3092\u4e9c\u785d\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u304a\u3088\u3073\u5869\u9178\u3067\u51e6\u7406\u3057\u3066\u3001\u30b8\u30a2\u30be\u30cb\u30a6\u30e0\u5869\u3092\u5f62\u6210\u3059\u308b\u3002\u6b21\u306b\u3001\u3053\u306e\u5869\u306f\u9162\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u304a\u3088\u3073\u7121\u6c34\u9162\u9178\u3068\u53cd\u5fdc\u3057\u30664-\u30a2\u30bb\u30c8\u30ad\u30b7-3-\u30cb\u30c8\u30ed\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u304c\u5f97\u3089\u308c\u3001\u3053\u308c\u3092\u30b9\u30ba\u304a\u3088\u3073\u5869\u9178\u3067\u9084\u5143\u3057\u3066\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3092\u751f\u6210\u3057\u307e\u3059\u3002<\/p>\n<p>\u5225\u306e\u65b9\u6cd5\u306b\u306f\u3001\u6c34\u9178\u5316\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u5b58\u5728\u4e0b\u3067p-\u30cb\u30c8\u30ed\u30a2\u30cb\u30ea\u30f3\u3068\u30af\u30ed\u30ed\u30ae\u9178\u30a8\u30c1\u30eb\u3092\u53cd\u5fdc\u3055\u305b\u3066\u3001p-\u30cb\u30c8\u30ed\u30d5\u30a7\u30cb\u30eb\u30ab\u30eb\u30d0\u30df\u30f3\u9178\u30a8\u30c1\u30eb\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u542b\u307e\u308c\u308b\u3002\u6b21\u306b\u3001\u3053\u306e\u5316\u5408\u7269\u3092\u6c34\u7d20\u30ac\u30b9\u3068\u30d1\u30e9\u30b8\u30a6\u30e0\u89e6\u5a92\u3067\u9084\u5143\u3057\u3066\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3092\u751f\u6210\u3057\u307e\u3059\u3002<\/p>\n<p> 3 \u756a\u76ee\u306e\u65b9\u6cd5\u3067\u306f\u30014-\u30cb\u30c8\u30ed\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u3092\u4e9c\u925b\u672b\u3068\u5869\u9178\u3067\u9084\u5143\u3057\u3066\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3092\u751f\u6210\u3057\u307e\u3059\u3002<\/p>\n<p>\u4f7f\u7528\u3059\u308b\u5408\u6210\u65b9\u6cd5\u306b\u95a2\u4fc2\u306a\u304f\u3001\u7d14\u7c8b\u306a\u751f\u6210\u7269\u3092\u5f97\u308b\u306b\u306f\u3001\u5f97\u3089\u308c\u305f\u5316\u5408\u7269\u3092\u518d\u7d50\u6676\u307e\u305f\u306f\u305d\u306e\u4ed6\u306e\u65b9\u6cd5\u3067\u7cbe\u88fd\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306f\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u5c40\u6240\u9ebb\u9154\u85ac\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u533b\u85ac\u54c1\u3084\u5316\u7ca7\u54c1\u306e\u88fd\u9020\u306b\u3082\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n<h5 class=\"wp-block-heading\"> <strong>4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306e\u7528\u9014<\/strong><\/h5>\n<p>\u4e00\u822c\u7684\u306a\u5c40\u6240\u9ebb\u9154\u85ac\u3067\u3042\u308b\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306f\u3001\u60a3\u90e8\u3092\u9ebb\u75fa\u3055\u305b\u3001\u8efd\u5ea6\u306e\u76ae\u819a\u708e\u3001\u5589\u306e\u75db\u307f\u3001\u6b6f\u75db\u3001\u6b6f\u304c\u751f\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u75db\u307f\u3084\u304b\u3086\u307f\u3092\u4e00\u6642\u7684\u306b\u548c\u3089\u3052\u307e\u3059\u3002\u30af\u30ea\u30fc\u30e0\u3001\u30b8\u30a7\u30eb\u3001\u30b9\u30d7\u30ec\u30fc\u3001\u30c8\u30ed\u30fc\u30c1\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u5f62\u72b6\u3067\u5165\u624b\u3067\u304d\u3001\u533b\u85ac\u54c1\u3084\u5316\u7ca7\u54c1\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u65e5\u713c\u3051\u3084\u5507\u306e\u8352\u308c\u306b\u3088\u308b\u75db\u307f\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306e\u54b3\u6b62\u3081\u30c9\u30ed\u30c3\u30d7\u3001\u306e\u3069\u30b9\u30d7\u30ec\u30fc\u3001\u53e3\u8154\u93ae\u75db\u5264\u3001\u65e5\u713c\u3051\u6b62\u3081\u30ed\u30fc\u30b7\u30e7\u30f3\u3001\u30ea\u30c3\u30d7\u30af\u30ea\u30fc\u30e0\u306a\u3069\u306b\u3088\u304f\u4f7f\u308f\u308c\u308b\u6210\u5206\u3067\u3059\u3002<\/p>\n<p>\u98df\u54c1\u696d\u754c\u3067\u306f\u3001\u30ad\u30e3\u30f3\u30c7\u30a3\u30fc\u3001\u30c1\u30e5\u30fc\u30a4\u30f3\u30ac\u30e0\u3001\u305d\u306e\u4ed6\u306e\u83d3\u5b50\u88fd\u54c1\u306e\u9999\u6599\u3068\u3057\u3066\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u3092\u4f7f\u7528\u3057\u3001\u51b7\u5374\u52b9\u679c\u3084\u93ae\u75db\u52b9\u679c\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40 (FDA) \u306f\u3001\u98df\u54c1\u3078\u306e\u4f7f\u7528\u3092\u627f\u8a8d\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u30d9\u30f3\u30be\u30ab\u30a4\u30f3\u306f\u3001\u76ae\u819a\u306e\u708e\u75c7\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306a\u3069\u306e\u671b\u307e\u3057\u304f\u306a\u3044\u526f\u4f5c\u7528\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u3001\u533b\u7642\u5c02\u9580\u5bb6\u306e\u6307\u793a\u307e\u305f\u306f\u88fd\u54c1\u30e9\u30d9\u30eb\u306e\u6307\u5b9a\u306b\u5f93\u3063\u3066\u306e\u307f\u4f7f\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u6ce8\u610f\u3057\u3066\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<h5 class=\"wp-block-heading\"><strong>\u8cea\u554f:<\/strong><\/h5>\n<h6 class=\"wp-block-heading\"> 4-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306f\u6975\u6027\u3067\u3059\u304b?<\/h6>\n<p>\u306f\u3044\u30014-\u30a2\u30df\u30ce\u5b89\u606f\u9999\u9178\u30a8\u30c1\u30eb\u306f\u6975\u6027\u3067\u3059\u3002\u6975\u6027\u5b98\u80fd\u57fa (\u30a2\u30df\u30ce\u57fa) 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